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Literature summary extracted from

  • Kim, Y.S.; Kolattukudy, P.E.; Boos, A.
    Malonyl-CoA decarboxylase from Mycobacterium tuberculosis and Pseudomonas fluorescence (1979), Arch. Biochem. Biophys., 196, 543-551.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.9 acetyl-CoA
-
 Mycobacterium tuberculosis
4.1.1.9 acetyl-CoA insensitive Pseudomonas fluorescens
4.1.1.9 Avidin no inhibition Mycobacterium tuberculosis
4.1.1.9 CoA
-
 Mycobacterium tuberculosis
4.1.1.9 CoA
-
 Pseudomonas fluorescens
4.1.1.9 methylmalonyl-CoA
-
 Mycobacterium tuberculosis
4.1.1.9 p-hydroxymercuribenzoate insensitive Pseudomonas fluorescens
4.1.1.9 propionyl-CoA
-
 Mycobacterium tuberculosis
4.1.1.9 propionyl-CoA insensitive Pseudomonas fluorescens
4.1.1.9 succinyl-CoA
-
 Mycobacterium tuberculosis
4.1.1.9 succinyl-CoA
-
 Pseudomonas fluorescens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.9 0.2
-
 malonyl-CoA
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.9 44000
-
 gel filtration Mycobacterium tuberculosis
4.1.1.9 56000
-
 gel filtration Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.9 Mycobacterium tuberculosis
-
-
-
4.1.1.9 Mycobacterium tuberculosis H37Ra / ATCC 25177
-
-
-
4.1.1.9 Pseudomonas fluorescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.9 partially Pseudomonas fluorescens
4.1.1.9 partially Mycobacterium tuberculosis

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.9 2.396
-
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.9 Malonyl-CoA
-
 Pseudomonas fluorescens Acetyl-CoA + CO2
-
 ?
4.1.1.9 Malonyl-CoA
-
 Mycobacterium tuberculosis Acetyl-CoA + CO2
-
 ?
4.1.1.9 Malonyl-CoA
-
 Mycobacterium tuberculosis H37Ra / ATCC 25177 Acetyl-CoA + CO2
-
 ?
4.1.1.9 methylmalonyl-CoA at 5% of the activity with malonyl-CoA Mycobacterium tuberculosis propionyl-CoA + CO2
-
 ?
4.1.1.9 methylmalonyl-CoA at 5% of the activity with malonyl-CoA Mycobacterium tuberculosis H37Ra / ATCC 25177 propionyl-CoA + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.9 5.5
-
-
 Pseudomonas fluorescens
4.1.1.9 5.5
-
-
 Mycobacterium tuberculosis