BRENDA - Enzyme Database

Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells

Tessitore, L.; Sesca, E.; Vance, D.E.; Int. J. Cancer 86, 362-367 (2000)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
Rattus norvegicus
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
S-adenosyl-L-homocysteine + phosphatidylcholine
-
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
Rattus norvegicus
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
Rattus norvegicus
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
Rattus norvegicus
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.17
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
hepatoma cell
PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma
Rattus norvegicus
-
2.1.1.17
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidylcholine
-
485195
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
-
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
485195
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
-
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
485195
Rattus norvegicus
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
Rattus norvegicus
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
S-adenosyl-L-homocysteine + phosphatidylcholine
-
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
Rattus norvegicus
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
Rattus norvegicus
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
Rattus norvegicus
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
hepatoma cell
PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma
Rattus norvegicus
-
2.1.1.17
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidylcholine
-
485195
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
-
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
485195
Rattus norvegicus
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
-
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
485195
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
485195
Rattus norvegicus
-