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Literature summary extracted from

  • Tessitore, L.; Sesca, E.; Vance, D.E.
    Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells (2000), Int. J. Cancer, 86, 362-367.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.17 S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine Rattus norvegicus the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine Rattus norvegicus the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.17 hepatoma cell PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma Rattus norvegicus
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2.1.1.17 liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.17 2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
-
 Rattus norvegicus 2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?