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Literature summary extracted from

  • Roque, M.E.; Giusto, N.M.
    Phosphatidylethanolamine N-methyltransferase activity in isolated rod outer segments from bovine retina (1995), Exp. Eye Res., 60, 631-643.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.17 0.037
-
 S-adenosylmethionine at pH 8.5 Bos taurus
2.1.1.17 0.038
-
 S-adenosylmethionine at pH 10 Bos taurus
2.1.1.71 0.037
-
 S-adenosyl-L-methionine pH 8.5 Bos taurus
2.1.1.71 0.038
-
 S-adenosyl-L-methionine pH 10.0 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.17 membrane intrinsic membrane protein Bos taurus 16020
-
2.1.1.71 cytosol
-
 Bos taurus 5829
-
2.1.1.71 membrane synaptosomal plasma membrane Rattus norvegicus 16020
-
2.1.1.71 microsome
-
 Rattus norvegicus
-
-
2.1.1.71 microsome
-
 Bos taurus
-
-
2.1.1.71 mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.17 Mg2+ required, maximal activity at 10 mM Bos taurus
2.1.1.71 Mg2+ requires magnesium ions for full activity Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.17 Bos taurus
-
-
-
2.1.1.71 Bos taurus
-
 bovine
-
2.1.1.71 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.71
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.17 retina rod outer segment Bos taurus
-
2.1.1.71 eye
-
 Bos taurus
-
2.1.1.71 liver
-
 Rattus norvegicus
-
2.1.1.71 retina rod outer segments Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Bos taurus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?
2.1.1.71 S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2.1.1.71 S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
-
 Bos taurus S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2.1.1.71 S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-monomethylethanolamine
-
 ?
2.1.1.71 S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Bos taurus S-adenosyl-L-homocysteine + phosphatidyl-N-monomethylethanolamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.71 PE N-MTase
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.17 8
-
 at low concentrations of S-adenosylmethionine, 0.01 mM Bos taurus
2.1.1.17 10
-
 at high concentrations of S-adenosylmethionine, 0.2 mM Bos taurus
2.1.1.71 8.5
-
 low substrate concentrations about 0.01 M S-adenosyl-L-methionine Bos taurus
2.1.1.71 10
-
-
 Rattus norvegicus
2.1.1.71 10
-
 high substrate concentrations about 0.2 M S-adenosyl-L-methionine Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.71 7 11
-
 Bos taurus