BRENDA - Enzyme Database

Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease

Guan, Z.Z.; Wang, Y.N.; Xiao, K.Q.; Hu, P.S.; Liu, J.L.; Neurochem. Int. 34, 41-47 (1999)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.17
Tween 20
stimulates
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.17
Triton X-100
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
Homo sapiens
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.17
Homo sapiens
-
-
-
2.1.1.71
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
brain
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease; frontal and occipital cortex
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485190
Homo sapiens
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease
485190
Homo sapiens
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.17
9
-
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.17
Tween 20
stimulates
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.17
Triton X-100
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
Homo sapiens
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
brain
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease; frontal and occipital cortex
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485190
Homo sapiens
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease
485190
Homo sapiens
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.17
9
-
-
Homo sapiens