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Literature summary extracted from

  • Guan, Z.Z.; Wang, Y.N.; Xiao, K.Q.; Hu, P.S.; Liu, J.L.
    Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease (1999), Neurochem. Int., 34, 41-47.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.17 Tween 20 stimulates Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.17 Triton X-100
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine Homo sapiens a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.17 Homo sapiens
-
-
-
2.1.1.71 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.17 brain frontal and occipital cortex Homo sapiens
-
2.1.1.17 brain a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Homo sapiens S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimer‘s disease Homo sapiens S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.17 9
-
-
 Homo sapiens