BRENDA - Enzyme Database

Why expression of phosphatidylethanolamine N-methyltransferase does not rescue Chinese hamster ovary cells that have an impaired CDP-choline pathway

Waite, K.A.; Vance, D.E.; J. Biol. Chem. 275, 21197-21202 (2000)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.17
Cricetulus griseus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
ovary cell line
ovary cell line MT58, with impaired CDP-choline pathway caused by a temperature-sensitive mutation in CTP:phosphocholine cytidyltransferase. PEMT2 expression fails to rescue the mutant cell line at 40°C because it does not maintain phosphatidylcholine levels required for cellular replication
Cricetulus griseus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485185
Cricetulus griseus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
ovary cell line
ovary cell line MT58, with impaired CDP-choline pathway caused by a temperature-sensitive mutation in CTP:phosphocholine cytidyltransferase. PEMT2 expression fails to rescue the mutant cell line at 40°C because it does not maintain phosphatidylcholine levels required for cellular replication
Cricetulus griseus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485185
Cricetulus griseus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?