BRENDA - Enzyme Database

Membrane topography of human phosphatidylethanolamine N-methyltransferase

Shields, D.J.; Lehner, R.; Agellon, L.B.; Vance, D.E.; J. Biol. Chem. 278, 2956-2962 (2003)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.17
endoplasmic reticulum
-
Homo sapiens
5783
-
2.1.1.17
membrane
; mitochondria-associated membrane; topographical model: 4 transmembrane regions span the membrane such that both the N and C termini of the enzyme are localized external to the ER. Two hydrophilic connecting loops protrude into the luminal face of the microsomes whereas a corresponding loop protrudes on the cytosolic side remains proximate to the membrane
Homo sapiens
16020
-
2.1.1.17
mitochondrion
; mitochondria associated membrane
Homo sapiens
5739
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.1.1.17
22000
-
x * 22000, SDS-PAGE, epitope-tagged protein
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.17
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485182
Homo sapiens
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.1.1.17
?
x * 22000, SDS-PAGE, epitope-tagged protein
Homo sapiens
2.1.1.17
More
membrane protein, four transmembrane regions, topographical model
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.17
endoplasmic reticulum
-
Homo sapiens
5783
-
2.1.1.17
membrane
; mitochondria-associated membrane; topographical model: 4 transmembrane regions span the membrane such that both the N and C termini of the enzyme are localized external to the ER. Two hydrophilic connecting loops protrude into the luminal face of the microsomes whereas a corresponding loop protrudes on the cytosolic side remains proximate to the membrane
Homo sapiens
16020
-
2.1.1.17
mitochondrion
; mitochondria associated membrane
Homo sapiens
5739
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.1.1.17
22000
-
x * 22000, SDS-PAGE, epitope-tagged protein
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.17
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.17
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485182
Homo sapiens
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.1.1.17
?
x * 22000, SDS-PAGE, epitope-tagged protein
Homo sapiens
2.1.1.17
More
membrane protein, four transmembrane regions, topographical model
Homo sapiens