BRENDA - Enzyme Database

Calmodulin- and calcium-insensitive fatty acid methyltransferase from RINm5F cells. Inhibition by trifluoperazine and W7

Safayhi, H.; Anazodo, M.I.; Ammon, H.P.T.; Int. J. Biochem. 23, 769-772 (1991)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.15
Ca2+
no effect below 0.5 mM
Rattus norvegicus
2.1.1.15
additional information
Ca2+, EGTA and calmodulin have no effect
Rattus norvegicus
2.1.1.15
N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide
W7, very strong inhibition
Rattus norvegicus
2.1.1.15
S-adenosylhomocysteine
-
Rattus norvegicus
2.1.1.15
Trifluoperazine
very strong inhibition
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.15
S-adenosyl-L-methionine + a fatty acid
Rattus norvegicus
involved in biosynthesis of phosphatidylcholine
S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
Rattus norvegicus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.15
Rattus norvegicus
-
insulinoma cell line RINm5F
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.15
retina
membrane
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.15
0.000018
-
-
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.15
S-adenosyl-L-methionine + a fatty acid
-
485161
Rattus norvegicus
S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
485161
Rattus norvegicus
?
2.1.1.15
S-adenosyl-L-methionine + a fatty acid
involved in biosynthesis of phosphatidylcholine
485161
Rattus norvegicus
S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
485161
Rattus norvegicus
?
2.1.1.15
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485161
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
485161
Rattus norvegicus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.15
Ca2+
no effect below 0.5 mM
Rattus norvegicus
2.1.1.15
additional information
Ca2+, EGTA and calmodulin have no effect
Rattus norvegicus
2.1.1.15
N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide
W7, very strong inhibition
Rattus norvegicus
2.1.1.15
S-adenosylhomocysteine
-
Rattus norvegicus
2.1.1.15
Trifluoperazine
very strong inhibition
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.15
S-adenosyl-L-methionine + a fatty acid
Rattus norvegicus
involved in biosynthesis of phosphatidylcholine
S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
Rattus norvegicus
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.15
retina
membrane
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.15
0.000018
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.15
S-adenosyl-L-methionine + a fatty acid
-
485161
Rattus norvegicus
S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
485161
Rattus norvegicus
?
2.1.1.15
S-adenosyl-L-methionine + a fatty acid
involved in biosynthesis of phosphatidylcholine
485161
Rattus norvegicus
S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
485161
Rattus norvegicus
?
2.1.1.15
S-adenosyl-L-methionine + phosphatidylethanolamine
-
485161
Rattus norvegicus
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
485161
Rattus norvegicus
?