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Literature summary extracted from

  • Zakharyan, R.; Wu, Y.; Bogdan, G.M.; Aposhian, H.V.
    Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver (1995), Chem. Res. Toxicol., 8, 1029-1038.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.137 dithiothreitol
-
 Oryctolagus cuniculus
2.1.1.137 glutathione
-
 Oryctolagus cuniculus
2.1.1.137 L-cysteine
-
 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.137 HgCl2
-
 Oryctolagus cuniculus
2.1.1.137 selenate more than 1 mM selenate necessary for 50% inhibition Oryctolagus cuniculus
2.1.1.137 Selenite 50% inhibition with 0.0126 mM selinite Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.137 cytosol
-
 Oryctolagus cuniculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.137 60000
-
 gel filtration Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite Oryctolagus cuniculus
-
 S-adenosyl-L-homocysteine + methylarsonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.137 DEAE cellulose, ammonium sulfate precipitation, Sephadex G-200, Sephadex G-100, 2000fold purification Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.137 0.00000167
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + methylarsonate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.137 6.8
-
 optimum if enzyme activity is measured in crude extracts Oryctolagus cuniculus
2.1.1.137 8.2
-
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.137 S-adenosyl-L-methionine
-
 Oryctolagus cuniculus