BRENDA - Enzyme Database show

Enzymatic methylation of arsenic compoundes. The marmoset and tamarin, but not the rhesus monkeys are deficient in methyltransferases that methylate inorganic compounds

Zakharyan, R.A.; Wildfang, E.; Aposhian, H.V.; Toxicol. Appl. Pharmacol. 140, 77-84 (1996)

Data extracted from this reference:

KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1.1.137
0.006
-
arsenite
-
Macaca mulatta
2.1.1.137
0.006
-
arsenite
-
Oryctolagus cuniculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.137
cytosol
-
Macaca mulatta
5829
-
2.1.1.137
cytosol
-
Oryctolagus cuniculus
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
Oryctolagus cuniculus
-
S-adenosyl-L-homocysteine + methylarsonate
-
Oryctolagus cuniculus
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
Macaca mulatta
-
S-adenosyl-L-homocysteine + methylarsonate
-
Macaca mulatta
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Macaca mulatta
-
rhesus monkey
-
2.1.1.137
no activity in Callithrix jacchus
-
marmoset monkey
-
2.1.1.137
no activity in Saguinus oedipus
-
tamarin monkeys
-
2.1.1.137
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.1.1.137
DEAE-cellulose, Sephadex G-200, Sephadex G-100, anion exchange chromatographie
Macaca mulatta
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
liver
-
Oryctolagus cuniculus
-
2.1.1.137
liver
-
Macaca mulatta
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.137
0.00000128
-
-
Macaca mulatta
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
485151
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + methylarsonate
-
485151
Oryctolagus cuniculus
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
485151
Macaca mulatta
S-adenosyl-L-homocysteine + methylarsonate
-
485151
Macaca mulatta
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.137
8
-
little activity at pH 7.0
Macaca mulatta
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.137
S-adenosyl-L-methionine
-
Macaca mulatta
2.1.1.137
S-adenosyl-L-methionine
-
Oryctolagus cuniculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.137
S-adenosyl-L-methionine
-
Macaca mulatta
2.1.1.137
S-adenosyl-L-methionine
-
Oryctolagus cuniculus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1.1.137
0.006
-
arsenite
-
Macaca mulatta
2.1.1.137
0.006
-
arsenite
-
Oryctolagus cuniculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.137
cytosol
-
Macaca mulatta
5829
-
2.1.1.137
cytosol
-
Oryctolagus cuniculus
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
Oryctolagus cuniculus
-
S-adenosyl-L-homocysteine + methylarsonate
-
Oryctolagus cuniculus
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
Macaca mulatta
-
S-adenosyl-L-homocysteine + methylarsonate
-
Macaca mulatta
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.1.1.137
DEAE-cellulose, Sephadex G-200, Sephadex G-100, anion exchange chromatographie
Macaca mulatta
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
liver
-
Oryctolagus cuniculus
-
2.1.1.137
liver
-
Macaca mulatta
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.137
0.00000128
-
-
Macaca mulatta
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
485151
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + methylarsonate
-
485151
Oryctolagus cuniculus
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
485151
Macaca mulatta
S-adenosyl-L-homocysteine + methylarsonate
-
485151
Macaca mulatta
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.137
8
-
little activity at pH 7.0
Macaca mulatta