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Literature summary extracted from

  • Zakharyan, R.A.; Wildfang, E.; Aposhian, H.V.
    Enzymatic methylation of arsenic compoundes. The marmoset and tamarin, but not the rhesus monkeys are deficient in methyltransferases that methylate inorganic compounds (1996), Toxicol. Appl. Pharmacol., 140, 77-84.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.137 0.006
-
 arsenite
-
 Oryctolagus cuniculus
2.1.1.137 0.006
-
 arsenite
-
 Macaca mulatta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.137 cytosol
-
 Oryctolagus cuniculus 5829
-
2.1.1.137 cytosol
-
 Macaca mulatta 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite Oryctolagus cuniculus
-
 S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + arsenite Macaca mulatta
-
 S-adenosyl-L-homocysteine + methylarsonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Macaca mulatta
-
 rhesus monkey
-
2.1.1.137 no activity in Callithrix jacchus
-
 marmoset monkey
-
2.1.1.137 no activity in Saguinus oedipus
-
 tamarin monkeys
-
2.1.1.137 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.137 DEAE-cellulose, Sephadex G-200, Sephadex G-100, anion exchange chromatographie Macaca mulatta

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.137 liver
-
 Oryctolagus cuniculus
-
2.1.1.137 liver
-
 Macaca mulatta
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.137 0.00000128
-
-
 Macaca mulatta

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Macaca mulatta S-adenosyl-L-homocysteine + methylarsonate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.137 8
-
 little activity at pH 7.0 Macaca mulatta

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.137 S-adenosyl-L-methionine
-
 Oryctolagus cuniculus
2.1.1.137 S-adenosyl-L-methionine
-
 Macaca mulatta