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Literature summary extracted from

  • Shen, R.S.; Smith, R.V.; Davis, P.J.; Brubaker, A.; Abell, C.W.
    Dopamine-derived tetrahydroisoquinolines. Novel inhibitors of dihydropteridine reductase (1982), J. Biol. Chem., 257, 7294-7297.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.34 3',4'-deoxynorlaudanosolinecarboxylic acid noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH Homo sapiens
1.5.1.34 aminopterin
-
 Homo sapiens
1.5.1.34 dopamine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 higenamine noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH Homo sapiens
1.5.1.34 higenamine-1-carboxylic acid noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 phenylpyruvate
-
 Homo sapiens
1.5.1.34 salsolinol noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 liver
-
 Homo sapiens
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.34 0.0015
-
 higenamine vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.0023
-
 higenamine vs. NADH Homo sapiens
1.5.1.34 0.0045
-
 higenamine-1-carboxylic acid vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.006
-
 dopamine vs. NADH Homo sapiens
1.5.1.34 0.0065
-
 dopamine vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.01
-
 aminopterin noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.01
-
 phenylpyruvic acid uncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.011
-
 aminopterin noncompetitive vs. NADH Homo sapiens
1.5.1.34 0.014
-
 3',4'-deoxynorlaudanosoline-carboxylic acid vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.031
-
 3',4'-deoxynorlaudanosoline-carboxylic acid vs. NADH Homo sapiens
1.5.1.34 0.09
-
 salsolinol
-
 Homo sapiens