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Literature summary extracted from

  • Dowhan, W.
    Phosphatidylserine decarboxylases: pyruvoyl-dependent enzymes from bacteria to mammals (1997), Methods Enzymol., 280, 81-88.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.65 pyruvate the pyruvoyl residue is covalently bound to the amino terminus of one of the two nonidentical subunits Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.65 44172
-
 1 * 3545, alpha, + 1 * 44172, beta Cricetulus griseus
4.1.1.65 52367
-
 1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1 Saccharomyces cerevisiae
4.1.1.65 118868
-
 1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.65 Cricetulus griseus
-
-
-
4.1.1.65 Escherichia coli
-
-
-
4.1.1.65 Homo sapiens
-
-
-
4.1.1.65 Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.1.1.65 side-chain modification the enzyme is synthesized as a single subunit proenzyme form, pi subunit, 35579 Da, which undergoes posttranslational processing in which an internal Ser residue becomes the covalently bound prosthetic group of one of the two resulting subunits Escherichia coli

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.65 phosphatidyl-L-serine = phosphatidylethanolamine + CO2 decarboxylation via Schiff base formation between a covalently bound pyruvoyl prosthetic group and the amine of serine Escherichia coli
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.65 ovary
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.65 Phosphatidyl-L-serine
-
 Cricetulus griseus Phosphatidylethanolamine + CO2
-
 ?
4.1.1.65 Phosphatidyl-L-serine
-
 Escherichia coli Phosphatidylethanolamine + CO2
-
 ?
4.1.1.65 Phosphatidyl-L-serine
-
 Homo sapiens Phosphatidylethanolamine + CO2
-
 ?
4.1.1.65 Phosphatidyl-L-serine
-
 Saccharomyces cerevisiae Phosphatidylethanolamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.65 dimer
-
 Escherichia coli
4.1.1.65 dimer 1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2 Saccharomyces cerevisiae
4.1.1.65 dimer 1 * 3545, alpha, + 1 * 44172, beta Cricetulus griseus
4.1.1.65 dimer 1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1 Saccharomyces cerevisiae