BRENDA - Enzyme Database

Phosphatidylserine decarboxylases: pyruvoyl-dependent enzymes from bacteria to mammals

Dowhan, W.; Methods Enzymol. 280, 81-88 (1997)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
4.1.1.65
pyruvate
the pyruvoyl residue is covalently bound to the amino terminus of one of the two nonidentical subunits
Escherichia coli
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.1.1.65
44172
-
1 * 3545, alpha, + 1 * 44172, beta
Cricetulus griseus
4.1.1.65
52367
-
1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1
Saccharomyces cerevisiae
4.1.1.65
118868
-
1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2
Saccharomyces cerevisiae
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.1.65
Cricetulus griseus
-
-
-
4.1.1.65
Escherichia coli
-
-
-
4.1.1.65
Homo sapiens
-
-
-
4.1.1.65
Saccharomyces cerevisiae
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
4.1.1.65
side-chain modification
the enzyme is synthesized as a single subunit proenzyme form, pi subunit, 35579 Da, which undergoes posttranslational processing in which an internal Ser residue becomes the covalently bound prosthetic group of one of the two resulting subunits
Escherichia coli
Reaction
EC Number
Reaction
Commentary
Organism
4.1.1.65
phosphatidyl-L-serine = phosphatidylethanolamine + CO2
decarboxylation via Schiff base formation between a covalently bound pyruvoyl prosthetic group and the amine of serine
Escherichia coli
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.1.1.65
ovary
-
Cricetulus griseus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.65
Phosphatidyl-L-serine
-
4785
Cricetulus griseus
Phosphatidylethanolamine + CO2
-
4785
Cricetulus griseus
-
4.1.1.65
Phosphatidyl-L-serine
-
4785
Escherichia coli
Phosphatidylethanolamine + CO2
-
4785
Escherichia coli
-
4.1.1.65
Phosphatidyl-L-serine
-
4785
Homo sapiens
Phosphatidylethanolamine + CO2
-
4785
Homo sapiens
-
4.1.1.65
Phosphatidyl-L-serine
-
4785
Saccharomyces cerevisiae
Phosphatidylethanolamine + CO2
-
4785
Saccharomyces cerevisiae
-
Subunits
EC Number
Subunits
Commentary
Organism
4.1.1.65
dimer
1 * 3545, alpha, + 1 * 44172, beta
Cricetulus griseus
4.1.1.65
dimer
-
Escherichia coli
4.1.1.65
dimer
1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2; 1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1
Saccharomyces cerevisiae
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
4.1.1.65
pyruvate
the pyruvoyl residue is covalently bound to the amino terminus of one of the two nonidentical subunits
Escherichia coli
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.1.1.65
44172
-
1 * 3545, alpha, + 1 * 44172, beta
Cricetulus griseus
4.1.1.65
52367
-
1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1
Saccharomyces cerevisiae
4.1.1.65
118868
-
1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2
Saccharomyces cerevisiae
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
4.1.1.65
side-chain modification
the enzyme is synthesized as a single subunit proenzyme form, pi subunit, 35579 Da, which undergoes posttranslational processing in which an internal Ser residue becomes the covalently bound prosthetic group of one of the two resulting subunits
Escherichia coli
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.1.1.65
ovary
-
Cricetulus griseus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.65
Phosphatidyl-L-serine
-
4785
Cricetulus griseus
Phosphatidylethanolamine + CO2
-
4785
Cricetulus griseus
-
4.1.1.65
Phosphatidyl-L-serine
-
4785
Escherichia coli
Phosphatidylethanolamine + CO2
-
4785
Escherichia coli
-
4.1.1.65
Phosphatidyl-L-serine
-
4785
Homo sapiens
Phosphatidylethanolamine + CO2
-
4785
Homo sapiens
-
4.1.1.65
Phosphatidyl-L-serine
-
4785
Saccharomyces cerevisiae
Phosphatidylethanolamine + CO2
-
4785
Saccharomyces cerevisiae
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
4.1.1.65
dimer
1 * 3545, alpha, + 1 * 44172, beta
Cricetulus griseus
4.1.1.65
dimer
-
Escherichia coli
4.1.1.65
dimer
1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2; 1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1
Saccharomyces cerevisiae