BRENDA - Enzyme Database

Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli

Satre, M.; Kennedy, E.P.; J. Biol. Chem. 253, 479-483 (1978)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.1.65
4-Bromo-3-hydroxybenzyloxyamine
-
Escherichia coli
4.1.1.65
Cyanoborohydride
inactivation in presence of phosphatidylserine, no inactivation in absence of phosphatidylserine
Escherichia coli
4.1.1.65
Hydrazines
phenylhydrazine
Escherichia coli
4.1.1.65
hydroxylamine
-
Escherichia coli
4.1.1.65
O-Benzylhydroxylamine
-
Escherichia coli
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.1.1.65
membrane
intrinsic membrane protein
Escherichia coli
16020
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.1.65
phosphatidyl-L-serine
Escherichia coli
the enzyme catalyzes the final step in the biosynthesis of phosphatidylethanolamine
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.1.65
Escherichia coli
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
4.1.1.65
phosphatidyl-L-serine = phosphatidylethanolamine + CO2
a Schiff base is formed by addition of the amino group of phosphatidylserine to the pyruvate residue of the enzyme as an essential step in the action of the decarboxylase
Escherichia coli
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.65
Phosphatidyl-L-serine
-
4769
Escherichia coli
Phosphatidylethanolamine + CO2
-
4769
Escherichia coli
-
4.1.1.65
phosphatidyl-L-serine
the enzyme catalyzes the final step in the biosynthesis of phosphatidylethanolamine
4769
Escherichia coli
?
-
-
-
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.1.65
4-Bromo-3-hydroxybenzyloxyamine
-
Escherichia coli
4.1.1.65
Cyanoborohydride
inactivation in presence of phosphatidylserine, no inactivation in absence of phosphatidylserine
Escherichia coli
4.1.1.65
Hydrazines
phenylhydrazine
Escherichia coli
4.1.1.65
hydroxylamine
-
Escherichia coli
4.1.1.65
O-Benzylhydroxylamine
-
Escherichia coli
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.1.1.65
membrane
intrinsic membrane protein
Escherichia coli
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.1.65
phosphatidyl-L-serine
Escherichia coli
the enzyme catalyzes the final step in the biosynthesis of phosphatidylethanolamine
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.65
Phosphatidyl-L-serine
-
4769
Escherichia coli
Phosphatidylethanolamine + CO2
-
4769
Escherichia coli
-
4.1.1.65
phosphatidyl-L-serine
the enzyme catalyzes the final step in the biosynthesis of phosphatidylethanolamine
4769
Escherichia coli
?
-
-
-
-