Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Da'dara, A.A.; Mett, H.; Walter, R.D.
    MGBG analogues as potent inhibitors of S-adenosylmethionine decarboxylase of Onchocerca volvulus (1998), Mol. Biochem. Parasitol., 97, 13-19.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 putrescine stimulation Onchocerca volvulus
4.1.1.50 putrescine maximal stimulation at 1 mM Onchocerca volvulus

Application

EC Number Application Comment Organism
4.1.1.50 pharmacology potentially important target for chemotherapy of filiarial infection Onchocerca volvulus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.50 expression in Escherichia coli Onchocerca volvulus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 4-Amidinoindan-1-(2'-amidino)hydrazone i.e. CGP 48664 Onchocerca volvulus
4.1.1.50 Berenil reversible Onchocerca volvulus
4.1.1.50 Bis[[3-(aminoiminomethyl)phenyl]methylene]carbonimidic dihydrazide trihydrochloride i.e. CGP 40215A Onchocerca volvulus
4.1.1.50 MDL 73811 irreversibel Onchocerca volvulus
4.1.1.50 methylglyoxal bis(guanylhydrazone) and analogues Onchocerca volvulus
4.1.1.50 additional information inhibited by CGP 51467A, CGP 48009A, and CGP 62577A Onchocerca volvulus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine Onchocerca volvulus key enzyme in polyamine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Onchocerca volvulus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
 Onchocerca volvulus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in polyamine biosynthesis Onchocerca volvulus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.50 7.5
-
-
 Onchocerca volvulus