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Literature summary extracted from

  • Sakai, T.; Hori, C.; Kano, K.; Oka, T.
    Purification and characterization of S-adenosyl-L-methionine decarboxylase from mouse mammary gland and liver (1979), Biochemistry, 18, 5541-5548.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 putrescine stimulation Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 spermidine
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.50 0.02 0.11 S-adenosyl-L-methionine
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.50 32000
-
 2 * 32000, SDS-PAGE Mus musculus
4.1.1.50 68000
-
 gel filtration Mus musculus
4.1.1.50 74000
-
 sucrose density gradient centrifugation Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine Mus musculus key enzyme in polyamine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.50
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.50 liver
-
 Mus musculus
-
4.1.1.50 mammary gland
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.50 0.102
-
-
 Mus musculus

Storage Stability

EC Number Storage Stability Organism
4.1.1.50 4°C, 10 mM Tris-HCl buffer, pH 7.6, in presence of 0.4 M NaCl and 0.01% deoxycholate, stable for at least 1 month Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
 Mus musculus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in polyamine biosynthesis Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.50 dimer 2 * 32000, SDS-PAGE Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.50 7.6
-
-
 Mus musculus