EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.50 | 1,3-diaminopropane | stimulates | Rattus norvegicus | |
4.1.1.50 | 1,3-diaminopropane | stimulates | Saccharomyces cerevisiae | |
4.1.1.50 | 1,3-diaminopropane | activates | Saccharomyces cerevisiae | |
4.1.1.50 | cadaverine | activates | Saccharomyces cerevisiae | |
4.1.1.50 | putrescine | required | Saccharomyces cerevisiae | |
4.1.1.50 | putrescine | stimulation | Mus musculus | |
4.1.1.50 | putrescine | stimulation | Homo sapiens | |
4.1.1.50 | putrescine | stimulation | Rattus norvegicus | |
4.1.1.50 | putrescine | stimulation | Saccharomyces cerevisiae | |
4.1.1.50 | putrescine | stimulation | Lytechinus pictus | |
4.1.1.50 | pyruvate | - |
Homo sapiens | |
4.1.1.50 | pyruvate | each subunit contains one covalently linked pyruvate | Escherichia coli | |
4.1.1.50 | pyruvate | each subunit contains one covalently linked pyruvate | Rattus norvegicus | |
4.1.1.50 | pyruvate | each subunit contains one covalently linked pyruvate | Saccharomyces cerevisiae | |
4.1.1.50 | spermidine | - |
Saccharomyces cerevisiae | |
4.1.1.50 | spermidine | - |
Lytechinus pictus | |
4.1.1.50 | spermidine | weak stimulation | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.50 | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt | - |
Escherichia coli | |
4.1.1.50 | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt | - |
Rattus norvegicus | |
4.1.1.50 | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt | - |
Saccharomyces cerevisiae | |
4.1.1.50 | 1,1'-[(Methylethanediylidene)dinitrilo] bis(3-aminoguanidine) | - |
Rattus norvegicus | |
4.1.1.50 | Dimethylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
4.1.1.50 | ethylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
4.1.1.50 | methylglyoxal bis(guanylhydrazone) | competitive | Escherichia coli | |
4.1.1.50 | methylglyoxal bis(guanylhydrazone) | - |
Homo sapiens | |
4.1.1.50 | methylglyoxal bis(guanylhydrazone) | - |
Lytechinus pictus | |
4.1.1.50 | methylglyoxal bis(guanylhydrazone) | - |
Mus musculus | |
4.1.1.50 | methylglyoxal bis(guanylhydrazone) | reversible | Rattus norvegicus | |
4.1.1.50 | methylglyoxal bis(guanylhydrazone) | - |
Saccharomyces cerevisiae | |
4.1.1.50 | NaBH4 | - |
Escherichia coli | |
4.1.1.50 | NaBH4 | - |
Saccharomyces cerevisiae | |
4.1.1.50 | NaCNBH3 | inactivation in presence of adenosylmethionine and Mg2+, no inactivation in absence of substrate and Mg2+ | Escherichia coli | |
4.1.1.50 | NaCNBH3 | - |
Rattus norvegicus | |
4.1.1.50 | phenylhydrazine | strong | Escherichia coli |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.50 | additional information | - |
additional information | - |
Rattus norvegicus | |
4.1.1.50 | 0.06 | - |
S-adenosylmethionine | - |
Escherichia coli |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.50 | Ca2+ | requires a divalent cation, Mg2+, Ca2+ or Mn2+ | Escherichia coli | |
4.1.1.50 | Mg2+ | requires a divalent cation, Mg2+, Ca2+ or Mn2+ | Escherichia coli | |
4.1.1.50 | Mn2+ | requires a divalent cation, Mg2+, Ca2+ or Mn2+ | Escherichia coli | |
4.1.1.50 | Mn2+ | affinity for Mn2+ is increased in presence of substrate | Escherichia coli | |
4.1.1.50 | additional information | no requirement for a divalent metal ion | Rattus norvegicus | |
4.1.1.50 | additional information | no requirement for a divalent metal ion | Saccharomyces cerevisiae |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.1.1.50 | additional information | - |
- |
Rattus norvegicus |
4.1.1.50 | 17000 | - |
6 * 17000 | Escherichia coli |
4.1.1.50 | 41000 | - |
2 * 41000, SDS-PAGE | Saccharomyces cerevisiae |
4.1.1.50 | 88000 | - |
non-denaturing PAGE | Saccharomyces cerevisiae |
4.1.1.50 | 108000 | - |
- |
Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.50 | S-adenosyl-L-methionine | Mus musculus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Escherichia coli | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Homo sapiens | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Rattus norvegicus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Saccharomyces cerevisiae | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Bos taurus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Lytechinus pictus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Mus musculus | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Homo sapiens | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Rattus norvegicus | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | Bos taurus | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.50 | Bos taurus | - |
calf | - |
4.1.1.50 | Escherichia coli | - |
- |
- |
4.1.1.50 | Homo sapiens | - |
- |
- |
4.1.1.50 | Lytechinus pictus | - |
- |
- |
4.1.1.50 | Mus musculus | - |
- |
- |
4.1.1.50 | Rattus norvegicus | - |
- |
- |
4.1.1.50 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.50 | - |
Escherichia coli |
4.1.1.50 | - |
Homo sapiens |
4.1.1.50 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.1.1.50 | egg | - |
Lytechinus pictus | - |
4.1.1.50 | liver | - |
Mus musculus | - |
4.1.1.50 | liver | - |
Rattus norvegicus | - |
4.1.1.50 | liver | - |
Bos taurus | - |
4.1.1.50 | lymphocyte | - |
Bos taurus | - |
4.1.1.50 | mammary gland | - |
Mus musculus | - |
4.1.1.50 | muscle | - |
Rattus norvegicus | - |
4.1.1.50 | prostate gland | - |
Homo sapiens | - |
4.1.1.50 | prostate gland | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.50 | Adenosylethionine | poor substrate | Escherichia coli | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Mus musculus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Escherichia coli | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Homo sapiens | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Rattus norvegicus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Bos taurus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | - |
Lytechinus pictus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Mus musculus | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Escherichia coli | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Homo sapiens | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Rattus norvegicus | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Saccharomyces cerevisiae | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Bos taurus | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Lytechinus pictus | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Mus musculus | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Homo sapiens | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Rattus norvegicus | ? | - |
? | |
4.1.1.50 | S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Bos taurus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.1.1.50 | dimer | - |
Mus musculus |
4.1.1.50 | dimer | - |
Rattus norvegicus |
4.1.1.50 | dimer | 2 * 41000, SDS-PAGE | Saccharomyces cerevisiae |
4.1.1.50 | hexamer | 6 * 17000 | Escherichia coli |
4.1.1.50 | More | - |
Rattus norvegicus |