Literature summary extracted from

Bitonti, A.J.; Dumont, J.A.; McCann, P.P.
Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by berenil, pentamidine and methylglyoxal bis(guanylhydrazone) (1986), Biochem. J., 237, 685-689.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
4.1.1.50	putrescine	weak stimulation, relatively insensitive to activation as compared with the mammalian enzyme	Trypanosoma brucei

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.1.1.50	Berenil	irreversible	Trypanosoma brucei
4.1.1.50	methylglyoxal bis(guanylhydrazone)	irreversible	Trypanosoma brucei
4.1.1.50	Pentamidine	irreversible	Trypanosoma brucei

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.1.1.50	0.03	-	S-adenosyl-L-methionine	-	Trypanosoma brucei

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.50	Trypanosoma brucei	-	brucei	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.1.50	S-adenosyl-L-methionine	-	Trypanosoma brucei	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?

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Release 2023.1 (January 2023)