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Literature summary extracted from

  • Kamath, A.V.; Vaidyanathan, C.S.
    New pathway for the biodegradation of indole in Aspergillus niger (1990), Appl. Environ. Microbiol., 56, 275-280.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.13.35 indole 0.02% induces the enzyme 516fold Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.35 anthranilate + NADPH + O2 Aspergillus niger metabolism of indole 2,3-dihydroxybenzoate + NADP+ + NH3
-
 ?
4.1.1.46 2,3-Dihydroxybenzoate Aspergillus niger enzyme is involved in the pathway for the biodegradation of indole, enzyme is induced by indole ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.35 Aspergillus niger
-
-
-
4.1.1.46 Aspergillus niger
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.35 0.05
-
 in cell extracts grown on glucose Aspergillus niger
1.14.13.35 25.8
-
 in cell extracts grown on glucose plus indole Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.35 anthranilate + NADPH + O2
-
 Aspergillus niger 2,3-dihydroxybenzoate + NADP+ + NH3
-
 ?
1.14.13.35 anthranilate + NADPH + O2 metabolism of indole Aspergillus niger 2,3-dihydroxybenzoate + NADP+ + NH3
-
 ?
4.1.1.46 2,3-Dihydroxybenzoate
-
 Aspergillus niger Catechol + CO2
-
 ?
4.1.1.46 2,3-Dihydroxybenzoate enzyme is involved in the pathway for the biodegradation of indole, enzyme is induced by indole Aspergillus niger ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.35 8
-
 assay at Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.35 NADPH
-
 Aspergillus niger