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Literature summary extracted from
- o-Pyrocatechuic acid carboxy-lyase from Aspergillus niger (1967), Arch. Biochem. Biophys., 122, 466-473.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.46 | 2,3,4-Trihydroxybenzoate | - |
Aspergillus niger |  |
| 4.1.1.46 | 2,3-Dimercaptopropanol | - |
Aspergillus niger | |
| 4.1.1.46 | 2,4-Dihydroxybenzoate | competitive | Aspergillus niger | |
| 4.1.1.46 | 3-Hydroxyanthranilate | - |
Aspergillus niger | |
| 4.1.1.46 | AgNO3 | - |
Aspergillus niger | |
| 4.1.1.46 | CdCl2 | - |
Aspergillus niger | |
| 4.1.1.46 | CuSO4 | - |
Aspergillus niger | |
| 4.1.1.46 | cysteine | - |
Aspergillus niger | |
| 4.1.1.46 | FeCl3 | - |
Aspergillus niger | |
| 4.1.1.46 | FeSO4 | - |
Aspergillus niger | |
| 4.1.1.46 | HgCl2 | - |
Aspergillus niger | |
| 4.1.1.46 | iodoacetate | - |
Aspergillus niger | |
| 4.1.1.46 | Mercapotoethanol | weak | Aspergillus niger | |
| 4.1.1.46 | NEM | weak | Aspergillus niger | |
| 4.1.1.46 | o-phenanthroline | 1 mM, 50% inactivation | Aspergillus niger | |
| 4.1.1.46 | PCMB | - |
Aspergillus niger | |
| 4.1.1.46 | reduced glutathione | - |
Aspergillus niger | |
| 4.1.1.46 | salicylate | competitive | Aspergillus niger | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.46 | 0.3 | - |
2,3-Dihydroxybenzoate | - |
Aspergillus niger | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.46 | 2,3-Dihydroxybenzoate | Aspergillus niger | enzyme is involved in the biosynthesis of catechol | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.46 | Aspergillus niger | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.46 | - |
Aspergillus niger |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.46 | 22 | - |
- |
Aspergillus niger |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.46 | 2,3-Dihydroxybenzoate | - |
Aspergillus niger | Catechol + CO2 | - |
? | |
| 4.1.1.46 | 2,3-Dihydroxybenzoate | enzyme is involved in the biosynthesis of catechol | Aspergillus niger | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.46 | 42 | - |
- |
Aspergillus niger |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.46 | 5.2 | - |
- |
Aspergillus niger |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.46 | 4.5 | 7 | pH 4.5: about 35% of maximal activity, pH 7.0: about 30% of maximal activity | Aspergillus niger |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.46 | additional information | the enzyme does not contain a prosthetic group | Aspergillus niger |
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