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Literature summary extracted from

  • Egashira, Y.; Kouhashi, H.; Ohta, T.; Sanada, H.
    Purification and properties of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), key enzyme of niacin synthesis from tryptophan, from hog kidney (1996), J. Nutr. Sci. Vitaminol., 42, 173-183.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.45 diethyldicarbonate
-
Sus scrofa
4.1.1.45 iodoacetamide
-
Sus scrofa
4.1.1.45 Monoiodoacetic acid
-
Sus scrofa
4.1.1.45 N-Acetylimidazole
-
Sus scrofa
4.1.1.45 NEM
-
Sus scrofa
4.1.1.45 PCMB
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.45 0.0161
-
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.45 41000
-
1 * 41000, SDS-PAGE Sus scrofa
4.1.1.45 58000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Sus scrofa key enzyme of niacin synthesis from Trp ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.45 Sus scrofa
-
hog
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.45
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.45 kidney
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.45 3.789
-
-
Sus scrofa

Storage Stability

EC Number Storage Stability Organism
4.1.1.45 -20°C, 50 mM potassium phosphate buffer, pH 7.0, 0.14 M KCl, 5 mM 2-mercaptoethanol, 1 mM dithiothreitol, 1 mM EDTA, 20% glycerol, stable for at least 1 month Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Sus scrofa 2-aminomuconate semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate key enzyme of niacin synthesis from Trp Sus scrofa ?
-
?

Subunits

EC Number Subunits Comment Organism
4.1.1.45 monomer 1 * 41000, SDS-PAGE Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.45 7.5
-
-
Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.45 6 9 pH 6: about 40% of maximal activity, pH 9.0: about 35% of maximal activity Sus scrofa