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Literature summary extracted from

  • Ichiyama, A.; Nakamura, S.; Kawai, H.; Honjo, T.; Nishizuka, Y.; Hayaishi, O.; Senoh, S.
    Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues II. Enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid (1965), J. Biol. Chem., 240, 740-749.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.32 Co2+
-
 Felis catus
1.2.1.32 Cu2+
-
 Felis catus
1.2.1.32 Hg2+
-
 Felis catus
1.2.1.32 Ni2+
-
 Felis catus
1.2.1.32 p-chloromercuribenzoate
-
 Felis catus
4.1.1.45 2-hydroxymuconate 6-semialdehyde
-
 Felis catus
4.1.1.45 CuSO4
-
 Felis catus
4.1.1.45 HgCl2
-
 Felis catus
4.1.1.45 PCMB inhibition is prevented by either reduced glutathione or caseine Felis catus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.32 0.016
-
 2-hydroxymuconate-6-semialdehyde
-
 Felis catus
1.2.1.32 0.019
-
 NAD+
-
 Felis catus
4.1.1.45 0.001
-
 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.32 2-aminomuconate-6-semialdehyde + NAD+ + H2O Felis catus metabolism of benzene ring of tryptophan in mammalian tissues 2-aminomuconate + NADH
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Felis catus enzyme is involved in the metabolism of the benzene ring ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.32 Felis catus
-
-
-
4.1.1.45 Felis catus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.32
-
 Felis catus
4.1.1.45
-
 Felis catus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.45 liver
-
 Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.32 0.0765
-
-
 Felis catus
4.1.1.45 additional information
-
-
 Felis catus

Storage Stability

EC Number Storage Stability Organism
4.1.1.45 -20°C, stable for several months Felis catus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.32 2-aminomuconate-6-semialdehyde + NAD+ + H2O
-
 Felis catus 2-aminomuconate + NADH
-
 ?
1.2.1.32 2-aminomuconate-6-semialdehyde + NAD+ + H2O metabolism of benzene ring of tryptophan in mammalian tissues Felis catus 2-aminomuconate + NADH
-
 ?
1.2.1.32 2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + NAD+ + H2O synonym 5-methyl-2-hydroxymuconic-6-semialdehyde Felis catus 2-hydroxy-5-methylmuconate + NADH
-
 ?
1.2.1.32 2-hydroxymuconate-6-semialdehyde + NAD+ + H2O
-
 Felis catus 2-hydroxymuconate + NADH
-
 ?
1.2.1.32 acetaldehyde + NAD+ + H2O low activity Felis catus acetate + NADH + H+
-
 ?
1.2.1.32 formaldehyde + NAD+ + H2O
-
 Felis catus formate + NADH
-
 ?
1.2.1.32 n-butanal + NAD+ + H2O
-
 Felis catus n-butanoate + NADH + H+
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Felis catus 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate enzyme is involved in the metabolism of the benzene ring Felis catus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.32 7.5 8
-
 Felis catus
4.1.1.45 6 9.5
-
 Felis catus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.32 7 9 more than 50% of maximal activity between pH 7 and 9 Felis catus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
4.1.1.45 6 9.5 stable Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.32 NAD+ specific for, not replaceable by NADP+ Felis catus