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Literature summary extracted from
- The interactions of acetoacetate decarboxylase with carbonyl compounds, hydrogen cyanide, and an organic mercurial (1970), J. Biol. Chem., 245, 5214-5222.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.4 | beta-Diketones | - |
Clostridium acetobutylicum | |
| 4.1.1.4 | Borohydride | - |
Clostridium acetobutylicum |  |
| 4.1.1.4 | HCN- | inhibitory synergism between cyanide and carbonyl compounds. The effectiveness in descending order: acetaldehyde, acetone, cyclohexanone, methyl ethyl ketone, 3-hexanone, diethyl ketone | Clostridium acetobutylicum | |
| 4.1.1.4 | p-chloromercuriphenyl sulfonate | reversal by Cys | Clostridium acetobutylicum | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.4 | Clostridium acetobutylicum | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.4 | 2-Oxo-3-phenylpropionic acid | i.e. phenylacetoacetate | Clostridium acetobutylicum | Acetophenone + CO2 | - |
? | |
| 4.1.1.4 | Acetoacetate | - |
Clostridium acetobutylicum | Acetone + CO2 | - |
? | |
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Release 2023.1 (January 2023)
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