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Literature summary extracted from

  • Kawanishi, S.; Seki, Y.; Sano, S.
    Uroporphyrinogen decarboxylase. Purification, properties, and inhibition by polychlorinated biphenyl isomers (1983), J. Biol. Chem., 258, 4285-4292.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.37 2,3,2',3'-Tetrachlorobiphenyl
-
 Gallus gallus
4.1.1.37 2,3,4,2',3',4'-Hexachlorobiphenyl
-
 Gallus gallus
4.1.1.37 2,4,2',4'-Tetrachlorobiphenyl
-
 Gallus gallus
4.1.1.37 2,4,6,2',4',6'-Hexachlorobiphenyl
-
 Gallus gallus
4.1.1.37 2,5,2',5'-Tetrachlorobiphenyl
-
 Gallus gallus
4.1.1.37 2,6,2',6'-Tetrachlorobiphenyl
-
 Gallus gallus
4.1.1.37 3,4,3',4'-Tetrachlorobiphenyl
-
 Gallus gallus
4.1.1.37 3,4,5,3',4',5'-Hexachlorobiphenyl
-
 Gallus gallus
4.1.1.37 3,5,3',5'-Tetrachlorobiphenyl
-
 Gallus gallus
4.1.1.37 5,5'-dithiobis(2-nitrobenzoate)
-
 Gallus gallus
4.1.1.37 acetone
-
 Gallus gallus
4.1.1.37 diethyldicarbonate
-
 Gallus gallus
4.1.1.37 ethanol
-
 Gallus gallus
4.1.1.37 Isopropyl alcohol
-
 Gallus gallus
4.1.1.37 methanol
-
 Gallus gallus
4.1.1.37 NEM
-
 Gallus gallus
4.1.1.37 PCMB
-
 Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.37 39700
-
 2 * 39700, SDS-PAGE Gallus gallus
4.1.1.37 79000
-
 gel filtration Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.37 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.37 erythrocyte
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.37 0.0237
-
-
 Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.37 uroporphyrinogen I
-
 Gallus gallus coproporphyrinogen I + 4 CO2
-
 ?
4.1.1.37 Uroporphyrinogen III
-
 Gallus gallus Coproporphyrinogen III + 4 CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.37 dimer 2 * 39700, SDS-PAGE Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.37 6.8
-
 uroporphyrinogen III Gallus gallus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.37 6 7.4 pH 6.0: about 55% of maximal activity, pH 7.4: about 50% of maximal activity, uroporphyrinogen III Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.37 additional information contains no pyridoxal phosphate, flavin and heme Gallus gallus