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Literature summary extracted from
- Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase (1958), J. Biol. Chem., 232, 1141-1162.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.37 | Cu2+ | strong | Oryctolagus cuniculus |  |
| 4.1.1.37 | Hg2+ | strong | Oryctolagus cuniculus | |
| 4.1.1.37 | iodoacetamide | strong | Oryctolagus cuniculus | |
| 4.1.1.37 | Mn2+ | strong | Oryctolagus cuniculus | |
| 4.1.1.37 | O2 | autooxidation of uroporphyrinogen | Oryctolagus cuniculus | |
| 4.1.1.37 | PCMB | strong | Oryctolagus cuniculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.37 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.37 | reticulocyte | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.37 | uroporphyrinogen I | at 50% of the activity with uroporphyrinogen III | Oryctolagus cuniculus | coproporphyrinogen I + 4 CO2 | - |
? | |
| 4.1.1.37 | Uroporphyrinogen III | - |
Oryctolagus cuniculus | Coproporphyrinogen III + 4 CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.37 | 6.8 | - |
- |
Oryctolagus cuniculus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.37 | 5.3 | 8 | pH 5.3: about 60% of maximal activity, pH 8.0: about 65% of maximal activity | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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