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Literature summary extracted from
- Purification of a protein histidine kinase from the yeast Saccharomyces cerevisiae. The first member of this class of protein kinases (1991), J. Biol. Chem., 266, 9023-9031.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.13.1 | KCl | - |
Saccharomyces cerevisiae |  |
| 2.7.13.1 | NaCl | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.7.13.1 | 0.017 | - |
histone H4 | - |
Saccharomyces cerevisiae | |
| 2.7.13.1 | 0.06 | - |
ATP | ATP in form of MgATP2- | Saccharomyces cerevisiae | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.13.1 | Co2+ | 2 mM, activation | Saccharomyces cerevisiae | |
| 2.7.13.1 | Mg2+ | 15-20 mM, activation | Saccharomyces cerevisiae | |
| 2.7.13.1 | Mn2+ | 1.5 mM, activation | Saccharomyces cerevisiae | |
| 2.7.13.1 | additional information | not activated by Ca2+, Zn2+, Fe2+, Cu2+ | Saccharomyces cerevisiae |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.7.13.1 | 32000 | - |
gel filtration | Saccharomyces cerevisiae |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.13.1 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.7.13.1 | - |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.7.13.1 | 0.19 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.13.1 | ATP + histone H4 | - |
Saccharomyces cerevisiae | ADP + phosphohistone H4 | phosphorylation of His 75 | ? | |
| 2.7.13.1 | ATP + histone H4 L-histidine | - |
Saccharomyces cerevisiae | ADP + histone H4 Npi-phospho-L-histidine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.7.13.1 | monomer | 1 * 32000, SDS-PAGE | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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