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Literature summary extracted from

  • Weisiger, R.A.; Jakoby, W.B.
    Thiol S-methyltransferase from rat liver (1979), Arch. Biochem. Biophys., 196, 631-637.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.1.1.9 freezing destroys activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.9 S-adenosyl-L-homocysteine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.9 additional information
-
 additional information
-
 Rattus norvegicus
2.1.1.9 0.00054
-
 4-Chlorothiophenol
-
 Rattus norvegicus
2.1.1.9 0.0011
-
 phenyl sulfide
-
 Rattus norvegicus
2.1.1.9 0.0028
-
 4-Nitrothiophenol
-
 Rattus norvegicus
2.1.1.9 0.012
-
 Diethylthiocarbamoyl sulfide
-
 Rattus norvegicus
2.1.1.9 0.043
-
 2-Thioacetanilide
-
 Rattus norvegicus
2.1.1.9 0.11
-
 2-Benzimidazole thiol
-
 Rattus norvegicus
2.1.1.9 0.19
-
 thioglycolic acid
-
 Rattus norvegicus
2.1.1.9 0.21
-
 L-cysteine methyl ester
-
 Rattus norvegicus
2.1.1.9 0.4
-
 N-acetyl-L-cysteine
-
 Rattus norvegicus
2.1.1.9 1
-
 6-Propyl-2-thiouracil
-
 Rattus norvegicus
2.1.1.9 1.2
-
 2-mercaptopropionic acid
-
 Rattus norvegicus
2.1.1.9 1.4
-
 1-methylimidazol-2-thiol
-
 Rattus norvegicus
2.1.1.9 1.6
-
 2,3-Dimercaptopropanol
-
 Rattus norvegicus
2.1.1.9 4.7
-
 3-mercaptopropionic acid methyl ester
-
 Rattus norvegicus
2.1.1.9 8.1
-
 2-mercaptoethanol
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.9 27500
-
 1 * 27500, SDS-PAGE Rattus norvegicus
2.1.1.9 28000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.9
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.9 S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.9 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.9 0.01
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.9 1-methylimidazole-2-thiol + S-adenosyl-L-methionine
-
 Rattus norvegicus 1-methyl-2-(methylthio)-1H-imidazole + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2,3-dimercaptopropanol + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-benzimidazole thiol + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-mercaptobenzothiazole + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-2-mercaptobenzothiazole + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-mercaptoethanol + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-2-mercaptoethanol + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-mercaptopropionic acid + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-thioacetanilide + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-2-thioacetanilide + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 3-mercaptopropionic acid methyl ester + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-3-mercaptopropionic acid methyl ester + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 4-chlorothiophenol + S-adenosyl-L-methionine
-
 Rattus norvegicus 4-chloro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 4-nitrothiophenol + S-adenosyl-L-methionine
-
 Rattus norvegicus 4-nitro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 6-propyl-2-thiouracil + S-adenosyl-L-methionine
-
 Rattus norvegicus 6-propyl-S-methyl-2-thiouracil + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 6-thiopurine + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-6-thiopurine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 benzylmercaptan + S-adenosyl-L-methionine
-
 Rattus norvegicus benzylmethylsulfide + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 diethylthiocarbamoyl sulfide + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 L-cysteine methyl ester + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 mercaptoacetic acid + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 N-acetyl-L-cysteine + S-adenosyl-L-methionine
-
 Rattus norvegicus N-acetyl-S-methyl-L-cysteine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 phenyl sulfide + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 thiophenol + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.9 monomer 1 * 27500, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.9 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.9 7.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.9 6.6 8.6 about 50% of maximum activity at pH 6.6 and pH 8.6 Rattus norvegicus