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Literature summary extracted from

  • Harvima, R.J.; Kajander, E.O.; Harvima, I.T.; Fraki, J.E.
    Purification and partial characterization of rat kidney histamine-N-methyltransferase (1985), Biochim. Biophys. Acta, 841, 42-49.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.8 iodoacetamide inhibition Rattus norvegicus

General Stability

EC Number General Stability Organism
2.1.1.8 dithiothreitol, 1 mM, stabilizes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.8 histamine
-
Rattus norvegicus
2.1.1.8 iodoacetamide complete inhibition at 0.01 mM Rattus norvegicus
2.1.1.8 Methylhistamine
-
Rattus norvegicus
2.1.1.8 methylthioadenosine
-
Rattus norvegicus
2.1.1.8 p-hydroxymercuribenzoate complete inhibition at 0.1 mM Rattus norvegicus
2.1.1.8 S-adenosylhomocysteine
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.8 0.0061
-
histamine
-
Rattus norvegicus
2.1.1.8 0.0071
-
S-adenosyl-L-methionine
-
Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.8 35000
-
x * 35000, SDS-PAGE Rattus norvegicus
2.1.1.8 36000
-
gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.8 renal enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 kidney
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.8 additional information
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.1.1.8 -80°C, 10 mM potassium phosphate buffer, pH 7.4, 10% glycerol, 1 mM dithiothreitol, 8 months, 16% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine
-
Rattus norvegicus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.8 ? x * 35000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.8 37
-
assay at Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.1.8 37
-
90 min, 1 mM dithiothreitol, stable, 40% loss of activity without addition of dithiothreitol Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.8 9 9.4
-
Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.8 7.3 10.3 about 50% of maximum activity at pH 7.3 and pH 10.3 Rattus norvegicus