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Literature summary extracted from

  • Barth, H.; Lorenz, W.; Niemeyer, I.
    Inhibition and activation of histamine methyltransferase by methylated histamines (1973), Hoppe-Seyler's Z. Physiol. Chem., 354, 1021-1026.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.8 5-Methylhistamine 0.001-0.5 mM, activation Sus scrofa
2.1.1.8 N',N'-dimethylhistamine 0.001-0.5 mM, activation Sus scrofa
2.1.1.8 Nalpha-methylhistamine 0.001-0.5 mM, activation Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.8 1-Methylhistamine strong Sus scrofa
2.1.1.8 2-Methylhistamine strong Sus scrofa
2.1.1.8 3-Methylhistamine strong Sus scrofa
2.1.1.8 5-Methylhistamine weak Sus scrofa
2.1.1.8 Nalpha-methylhistamine weak Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 mucosa antrum mucosa Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Sus scrofa S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.8 8.3
-
 N-methylhistamine Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.8 6.5 10.5 about 50% of maximum activity at pH 6.5 and pH 10.5, N-methylhistamine Sus scrofa