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Literature summary extracted from

  • Borchardt, R.T.; Cheng, C.F.
    Purification and characterization of rat heart and brain catechol methyltransferase (1978), Biochim. Biophys. Acta, 522, 49-62.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 Analogs of S-adenosyl-L-homocysteine overview: inhibition of the liver, heart and brain enzyme Rattus norvegicus
2.1.1.6 additional information inhibition by analogs of S-adenosyl-homcysteine Rattus norvegicus
2.1.1.6 S-adenosyl-L-homocysteine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.6 additional information
-
 additional information overview: Km values of liver, heart and brain enzymes with various substrates Rattus norvegicus
2.1.1.6 0.169
-
 norepinephrine heart Rattus norvegicus
2.1.1.6 0.276
-
 norepinephrine brain Rattus norvegicus
2.1.1.6 1.856
-
 norepinephrine liver Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 microsome
-
 Rattus norvegicus
-
-
2.1.1.6 soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.6 23000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.6 soluble and microsomal enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 brain
-
 Rattus norvegicus
-
2.1.1.6 heart
-
 Rattus norvegicus
-
2.1.1.6 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.6 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 norepinephrine + S-adenosyl-L-methionine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + normetanephrine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.6 0.022 0.04 S-adenosyl-L-homocysteine
-
 Rattus norvegicus