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Literature summary extracted from

  • Schirch, L.; Gross, T.
    Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases (1968), J. Biol. Chem., 243, 5651-5655.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 2-aminoisobutyrate
-
 Oryctolagus cuniculus
2.1.2.1 allothreonine
-
 Oryctolagus cuniculus
2.1.2.1 aminoisobutyrate
-
 Oryctolagus cuniculus
2.1.2.1 D-alanine
-
 Oryctolagus cuniculus
2.1.2.1 DL-allothreonine
-
 Oryctolagus cuniculus
2.1.2.1 glycine
-
 Oryctolagus cuniculus
2.1.2.1 L-serine
-
 Oryctolagus cuniculus
2.1.2.1 L-threonine
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.1 0.15 0.9 L-serine
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.1
-
 Oryctolagus cuniculus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.1 2.43
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Oryctolagus cuniculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate requirement, 4 mol per mol enzyme Oryctolagus cuniculus
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.1 additional information
-
 additional information comparison of Ki for allothreonine and threonine Oryctolagus cuniculus
2.1.2.1 0.7 0.9 L-serine
-
 Oryctolagus cuniculus
2.1.2.1 2.7
-
 DL-allothreonine
-
 Oryctolagus cuniculus
2.1.2.1 2.7 6.8 glycine
-
 Oryctolagus cuniculus
2.1.2.1 13 23 aminoisobutyrate
-
 Oryctolagus cuniculus
2.1.2.1 40 55 D-alanine
-
 Oryctolagus cuniculus
2.1.2.1 50
-
 L-threonine
-
 Oryctolagus cuniculus