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Literature summary extracted from

  • Whitefield, C.D.; Steers, E.J.; Weissbach, H.
    Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase (1970), J. Biol. Chem., 245, 390-401.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.14
-
Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.14 5-methyltetrahydropteroyl-alpha-glutamate
-
Escherichia coli
2.1.1.14 EDTA in absence of Mg2+ Escherichia coli
2.1.1.14 high ionic strength
-
Escherichia coli
2.1.1.14 Pteroyl-alpha-glutamylglutamic acid
-
Escherichia coli
2.1.1.14 Pteroyl-gamma-glutamyl-gamma-glutamylglutamic acid
-
Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.14 0.0044
-
5-methyltetrahydropteroyltriglutamate
-
Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.14 soluble
-
Escherichia coli
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.14 Mg2+ stimulates Escherichia coli
2.1.1.14 Mg2+ at low phosphate concentration, 0.1 mM, the Mg2+-stimulation is 4.5fold, smaller stimulation at higher concentrations of phosphate Escherichia coli
2.1.1.14 phosphate
-
Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.14 50800
-
x * 50800, equilibrium sedimentation of carboxymethylated enzyme in 5 M guanidine-HCl Escherichia coli
2.1.1.14 84000
-
equilibrium ultracentrifugation Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.14 Escherichia coli
-
K12
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.14
-
Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.14 2.5
-
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.14 5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
Escherichia coli tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
?
2.1.1.14 additional information 5-methyltetrahydropteroyl-alpha-glutamate or 5-methyl-tetrahydropteroyl-alpha-glutamylglutamate cannot replace the triglutamate folate derivative as methyl donor Escherichia coli ?
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.14 ? x * 50800, equilibrium sedimentation of carboxymethylated enzyme in 5 M guanidine-HCl Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.14 7.5 7.8
-
Escherichia coli

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.14 6 8.5
-
Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.14 additional information vitamin-B12 independent enzyme Escherichia coli