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Literature summary extracted from

  • Rowe, P.M.; Wright, L.S.; Siegel, F.L.
    Calmodulin N-methyltransferase. Partial purification and characterization (1986), J. Biol. Chem., 261, 7060-7069.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.60 dithiothreitol stimulates Rattus norvegicus
2.1.1.60 Triton X-100
-
 Rattus norvegicus

General Stability

EC Number General Stability Organism
2.1.1.60 Triton stabilizes during purification Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.60 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.60 55000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.60 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.60
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.60 brain
-
 Rattus norvegicus
-
2.1.1.60 kidney
-
 Rattus norvegicus
-
2.1.1.60 additional information found at high levels in tissues with high levels of calmodulin, at low levels in tissues with low levels of calmodulin like liver, heart, skeletal muscle Rattus norvegicus
-
2.1.1.60 spleen
-
 Rattus norvegicus
-
2.1.1.60 testis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.60 additional information
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.1.1.60 -20°C, up to 2 weeks Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine highly specific Rattus norvegicus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine 3 mol of methyl per mol of calmodulin are incorporated into lysine 115 of des(methyl) calmodulin from Dictyostelium discoideum resulting in formation of 1 mol of trimethyllysine at the site normally methylated ?
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine Dictyostelium discoideum calmodulin Rattus norvegicus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine 3 mol of methyl per mol of calmodulin are incorporated into lysine 115 of des(methyl) calmodulin from Dictyostelium discoideum resulting in formation of 1 mol of trimethyllysine at the site normally methylated ?