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Literature summary extracted from

  • Sitaramayya, A.; Wright, L.S.; Siegel, F.L.
    Enzymatic methylation of calmodulin in rat brain cytosol (1980), J. Biol. Chem., 255, 8894-8900.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.60 dithiothreitol stimulates Rattus norvegicus
2.1.1.60 Mn2+ stimulation by divalent cations, Mn2+ giving highest activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.60 EGTA
-
 Rattus norvegicus
2.1.1.60 p-chloromercuriphenylsulfonic acid
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.60 additional information
-
 additional information
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.60 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.60 Mn2+ stimulation by divalent cations, Mn2+ giving highest activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.60 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.60 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.60 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine highly specific Rattus norvegicus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine trimethyllysine calmodulin, major product, + dimethyllysine + monomethyllysine ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.60 additional information
-
 pH 8.0, 7.8 or 6.0 depending on assay method Rattus norvegicus