Literature summary extracted from

Aksoy, S.; Szumlanski, C.L.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization (1994), J. Biol. Chem., 269, 14835-14840.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.1.1.1	-	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.1	N1-methylnicotinamide	IC50 0.06 mM for human protein, 0.03 mM for recombinant protein	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.1.1.1	0.0018	-	S-adenosyl-L-methionine	-	Homo sapiens
2.1.1.1	0.0022	-	S-adenosyl-L-methionine	recombinant protein	Homo sapiens
2.1.1.1	0.38	-	nicotinamide	recombinant protein	Homo sapiens
2.1.1.1	0.43	-	nicotinamide	-	Homo sapiens

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
2.1.1.1	29000	-	x * 29000, SDS-PAGE, recombinant protein	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.1	liver	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.1	S-adenosyl-L-methionine + nicotinamide	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-methylnicotinamide	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.1.1.1	?	x * 29000, SDS-PAGE, recombinant protein	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.1.1.1	0.06	-	IC50 0.06 mM for human protein, 0.03 mM for recombinant protein	Homo sapiens	N1-methylnicotinamide

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Release 2023.1 (January 2023)