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Literature summary extracted from

  • Madyastha, K.M.; Guarnaccia, R.; Baxter, C.; Coscia, C.L.
    S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea (1973), J. Biol. Chem., 248, 2497-2501.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.50 iodoacetamide
-
 Catharanthus roseus
2.1.1.50 KCN
-
 Catharanthus roseus
2.1.1.50 N-Methylmaleimide
-
 Catharanthus roseus
2.1.1.50 p-chloromercuribenzoate
-
 Catharanthus roseus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.50 12.5
-
 loganic acid
-
 Catharanthus roseus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.50 additional information dependency on divalent metal cations not detected Catharanthus roseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.50 S-adenosyl-L-methionine + loganate Catharanthus roseus biosynthesis of indole alkaloids S-adenosyl-L-homocysteine + loganin
-
 ?
2.1.1.50 S-adenosyl-L-methionine + secologanate Catharanthus roseus
-
 S-adenosyl-L-homocysteine + secologanin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.50 Catharanthus roseus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.50
-
 Catharanthus roseus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.50 additional information no significant methylation of: 7-deoxyloganic acid, geniposidic acid, 7-epiloganic acid Catharanthus roseus ?
-
 ?
2.1.1.50 S-adenosyl-L-methionine + loganate
-
 Catharanthus roseus S-adenosyl-L-homocysteine + loganin
-
 ?
2.1.1.50 S-adenosyl-L-methionine + loganate biosynthesis of indole alkaloids Catharanthus roseus S-adenosyl-L-homocysteine + loganin
-
 ?
2.1.1.50 S-adenosyl-L-methionine + secologanate
-
 Catharanthus roseus S-adenosyl-L-homocysteine + secologanin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.50 32 33 assay at Catharanthus roseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.50 7.2
-
 assay at Catharanthus roseus