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Literature summary extracted from
- Pantothenic acid and coenzyme A: phosphopantothenoylcysteine decarboxylase from rat liver [4'-phospho-N-(D-pantothenoyl)-L-cysteine carboxy-lyase, EC 4.1.1.36] (1970), Methods Enzymol., 18, 354-364.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.36 | cysteine | - |
Rattus norvegicus |  |
| 4.1.1.36 | GSH | activates | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.36 | ATP | reversed by equimolar amount of semicarbazide | Rattus norvegicus | |
| 4.1.1.36 | additional information | no effect of ADP and AMP | Rattus norvegicus | |
| 4.1.1.36 | pantotheine 4-phosphate | competitive product inhibition | Rattus norvegicus | |
| 4.1.1.36 | pyridoxal | - |
Rattus norvegicus | |
| 4.1.1.36 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
| 4.1.1.36 | UTP | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.36 | 0.133 | 0.15 | phosphopantothenoyl-L-Cys | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.36 | additional information | Mg2+ has no effect | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.36 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.36 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.36 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.36 | 0.03 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.36 | alpha-Carboxy-CoA | at low rate | Rattus norvegicus | ? | - |
? | |
| 4.1.1.36 | Dephospho-alpha-carboxy-CoA | at low rate | Rattus norvegicus | ? | - |
? | |
| 4.1.1.36 | additional information | pantothenylcysteine is decarboxylated | Rattus norvegicus | ? | - |
? | |
| 4.1.1.36 | N-((R)-4-Phosphopantothenoyl)-L-Cys | - |
Rattus norvegicus | Pantotheine 4-phosphate + CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.36 | 8 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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