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Literature summary extracted from
- Inactivation of L-lactate monooxygenase by nitration with tetranitromethane (1981), Arch. Biochem. Biophys., 210, 710-716.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.12.4 | (R)-lactate | - |
Mycolicibacterium phlei |  |
| 1.13.12.4 | acetate | - |
Mycolicibacterium phlei | |
| 1.13.12.4 | oxalate | - |
Mycolicibacterium phlei | |
| 1.13.12.4 | p-chloromercuribenzoate | 100% inhibition at 1.1 mM at pH 8 and 25°C after 30 min, excess of 2-mercaptoethanol protects | Mycolicibacterium phlei | |
| 1.13.12.4 | Tetranitromethane | 20 min at pH 8.0 and 1.5 mM; rapid and irreversible inactivation at 30°C, nitration of a single tyrosine per subunit, competitive inhibitors such as acetate, (R)-lactate or oxalate protect from inactivation | Mycolicibacterium phlei | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.12.4 | (S)-lactate + O2 | Mycolicibacterium phlei | - |
acetate + CO2 + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.12.4 | Mycolicibacterium phlei | - |
- |
- |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.13.12.4 | 4°C, 80% saturated ammonium sulfate in the dark | Mycolicibacterium phlei |
| 1.13.12.4 | 4°C, crystalline suspension in 1 M sodium acetate buffer, pH 5.4, in the dark | Mycolicibacterium phlei |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.12.4 | (S)-lactate + O2 | - |
Mycolicibacterium phlei | acetate + CO2 + H2O | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.12.4 | FMN | - |
Mycolicibacterium phlei | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.12.4 | 0.01 | - |
oxalate | - |
Mycolicibacterium phlei | |
| 1.13.12.4 | 4 | - |
(R)-lactate | - |
Mycolicibacterium phlei | |
| 1.13.12.4 | 11 | - |
acetate | - |
Mycolicibacterium phlei | |
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