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Literature summary extracted from

  • Helliwell, C.A.; Chandler, P.M.; Poole, A.; Dennis, E.S.; Peacock, W.J.
    The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway (2001), Proc. Natl. Acad. Sci. USA, 98, 2065-2070.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.107 expression in yeast Zea mays
1.14.14.107 expression in yeast Hordeum vulgare

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.107 ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 Zea mays the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 gibberellin A12 aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 Arabidopsis thaliana the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 gibberellin A12 aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 Hordeum vulgare the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 gibberellin A12 aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-kaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 Zea mays the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-kaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 Arabidopsis thaliana the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-kaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 Hordeum vulgare the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 gibberellin A12 aldehyde + [reduced NADPH-hemoprotein reductase] + O2 Zea mays the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 gibberellin A12 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 gibberellin A12 aldehyde + [reduced NADPH-hemoprotein reductase] + O2 Arabidopsis thaliana the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 gibberellin A12 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 gibberellin A12 aldehyde + [reduced NADPH-hemoprotein reductase] + O2 Hordeum vulgare the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 gibberellin A12 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.107 Arabidopsis thaliana
-
-
-
1.14.14.107 Hordeum vulgare Q9AXH9 dwarf mutant of barley that accumulates ent-keurenoic acid in developing grains
-
1.14.14.107 Zea mays
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.107 ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Zea mays gibberellin A12 aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Arabidopsis thaliana gibberellin A12 aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Hordeum vulgare gibberellin A12 aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-kaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Zea mays ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-kaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Arabidopsis thaliana ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 ent-kaur-16-en-19-oate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Hordeum vulgare ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 gibberellin A12 aldehyde + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Zea mays gibberellin A12 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 gibberellin A12 aldehyde + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Arabidopsis thaliana gibberellin A12 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.107 gibberellin A12 aldehyde + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12 Hordeum vulgare gibberellin A12 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.107 cytochrome P450 cytochrome P450 protein Zea mays
1.14.14.107 cytochrome P450 cytochrome P450 protein Hordeum vulgare