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Literature summary extracted from

  • Loke, P.; Sim, T.S.
    Analysis of glutamines in catalysis in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis (1998), Biochem. Biophys. Res. Commun., 252, 472-475.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.3.1 O2 required Acremonium chrysogenum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.3.1 overexpression of recombinant enzyme mutants in Cephalosporium acremonium Acremonium chrysogenum

Protein Variants

EC Number Protein Variants Comment Organism
1.21.3.1 Q227L site-directed mutagenesis, 55.10% remaining activity compared to wild-type Acremonium chrysogenum
1.21.3.1 Q337L site-directed mutagenesis, slightly reduced activity compared to wild-type Acremonium chrysogenum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.3.1 cytosol
-
Acremonium chrysogenum 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.21.3.1 Fe2+
-
Acremonium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Acremonium chrysogenum common step in the biosynthesis of penicillins, cephalosporins and cephamycins isopenicillin N + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.1 Acremonium chrysogenum
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.3.1 0.0000027
-
wild-type Acremonium chrysogenum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
Acremonium chrysogenum isopenicillin N + 2 H2O
-
?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 common step in the biosynthesis of penicillins, cephalosporins and cephamycins Acremonium chrysogenum isopenicillin N + 2 H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.21.3.1 IPNS
-
Acremonium chrysogenum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.3.1 26
-
assay at Acremonium chrysogenum