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Literature summary extracted from

  • Cote, J.F.; Roberge, A.G.
    Nitric oxide synthase in cat brain: cofactors - enzyme-substrate interaction (1996), Free Radic. Biol. Med., 21, 109-115.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 EDTA brain enzyme Felis catus
1.14.13.39 ethylene glycol bis(beta-amino-ethylether)-N,N,N',N'-tetraacetic acid
-
 Felis catus
1.14.13.39 N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide calmodulin antagonist above 0.01 mM; i.e. W-7 Felis catus
1.14.13.39 Ngamma-monomethyl-L-arginine
-
 Felis catus
1.14.13.39 Ngamma-nitro-L-arginine
-
 Felis catus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.39 0.011
-
 L-arginine with FAD and tetrahydropterin Felis catus
1.14.13.39 0.041
-
 L-arginine without tetrahydropterin and FAD Felis catus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 nucleus
-
 Felis catus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.39 Ca2+ required, calmodulin independent Felis catus

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Felis catus
-
 mongrel cat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 brain
-
 Felis catus
-
1.14.13.39 cerebral cortex
-
 Felis catus
-
1.14.13.39 hippocampus
-
 Felis catus
-
1.14.13.39 hypothalamus
-
 Felis catus
-
1.14.13.39 mesencephalon
-
 Felis catus
-
1.14.13.39 neostriatum
-
 Felis catus
-
1.14.13.39 pons
-
 Felis catus
-
1.14.13.39 thalamus
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Felis catus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 37
-
 assay at Felis catus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.39 7.5
-
-
 Felis catus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.14.13.39 6.6 8
-
 Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 5,6,7,8-tetrahydro-L-biopterin required Felis catus
1.14.13.39 Calmodulin required Felis catus
1.14.13.39 FAD
-
 Felis catus
1.14.13.39 FMN
-
 Felis catus
1.14.13.39 NADPH dependent on Felis catus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.13.39 0.000041
-
 Ngamma-nitro-L-arginine
-
 Felis catus
1.14.13.39 0.00031
-
 Ngamma-monomethyl-L-arginine
-
 Felis catus