EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.13.39 | rat brain enzyme expressed in human 293 kidney cells transfected with a vector encoding rat brain enzyme | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | CO | - |
Mus musculus | |
1.14.13.39 | CO | - |
Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | Iron | 2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy | Mus musculus | |
1.14.13.39 | Iron | 2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | Mus musculus | acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | Rattus norvegicus | acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.39 | Mus musculus | - |
- |
- |
1.14.13.39 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.13.39 | 2',5'-ADP-agarose affinity chromatography | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.14.13.39 | 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | cytochrome P-450 enzyme | Mus musculus | |
1.14.13.39 | 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | cytochrome P-450 enzyme | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.13.39 | brain | - |
Mus musculus | - |
1.14.13.39 | brain | - |
Rattus norvegicus | - |
1.14.13.39 | macrophage | cytokine-activated | Mus musculus | - |
1.14.13.39 | macrophage | cytokine-activated | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Mus musculus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | probably via Nomega-hydroxy-L-arginine | ? | |
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Rattus norvegicus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | probably via Nomega-hydroxy-L-arginine | ? | |
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity | Mus musculus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity | Rattus norvegicus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.13.39 | 37 | - |
assay at | Mus musculus |
1.14.13.39 | 37 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | FAD | FAD containing flavoprotein | Mus musculus | |
1.14.13.39 | FAD | FAD containing flavoprotein | Rattus norvegicus | |
1.14.13.39 | FMN | FMN containing flavoprotein | Mus musculus | |
1.14.13.39 | FMN | FMN containing flavoprotein | Rattus norvegicus | |
1.14.13.39 | NADPH | - |
Mus musculus | |
1.14.13.39 | NADPH | - |
Rattus norvegicus |