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Literature summary extracted from

  • Stuehr, D.J.; Ikeda-Saito, M.
    Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical (1992), J. Biol. Chem., 267, 20547-20550.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.39 rat brain enzyme expressed in human 293 kidney cells transfected with a vector encoding rat brain enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 CO
-
Mus musculus
1.14.13.39 CO
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.39 Iron 2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy Mus musculus
1.14.13.39 Iron 2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Mus musculus acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Mus musculus
-
-
-
1.14.13.39 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.39 2',5'-ADP-agarose affinity chromatography Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O cytochrome P-450 enzyme Mus musculus
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O cytochrome P-450 enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 brain
-
Mus musculus
-
1.14.13.39 brain
-
Rattus norvegicus
-
1.14.13.39 macrophage cytokine-activated Mus musculus
-
1.14.13.39 macrophage cytokine-activated Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O probably via Nomega-hydroxy-L-arginine ?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O probably via Nomega-hydroxy-L-arginine ?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 37
-
assay at Mus musculus
1.14.13.39 37
-
assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 FAD FAD containing flavoprotein Mus musculus
1.14.13.39 FAD FAD containing flavoprotein Rattus norvegicus
1.14.13.39 FMN FMN containing flavoprotein Mus musculus
1.14.13.39 FMN FMN containing flavoprotein Rattus norvegicus
1.14.13.39 NADPH
-
Mus musculus
1.14.13.39 NADPH
-
Rattus norvegicus