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Literature summary extracted from

  • Coque, J.J.R.; De la Fuente, J.L.; Liras, P.; Martin, J.F.
    Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide (1996), Eur. J. Biochem., 242, 264-270.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.26 overexpression in Streptomyces lividans Amycolatopsis lactamdurans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.26 430000
-
 gel filtration Amycolatopsis lactamdurans

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.26 Amycolatopsis lactamdurans
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.26
-
 Amycolatopsis lactamdurans

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.2.26 55.71
-
-
 Amycolatopsis lactamdurans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.26 6-oxopiperidine 2-carboxylic acid + L-cysteine + L-valine + ATP
-
 Amycolatopsis lactamdurans N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + L-cystathionine + L-valine + ATP
-
 Amycolatopsis lactamdurans N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + L-cysteine + L-valine + ATP
-
 Amycolatopsis lactamdurans N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.26 monomer 1 * 430000, SDS-PAGE Amycolatopsis lactamdurans

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.26 ATP
-
 Amycolatopsis lactamdurans