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Literature summary extracted from

  • Baldwin, J.E.; Shiau, C.Y.; Byford, M.F.; Schofield, C.J.
    Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products (1994), Biochem. J., 301, 367-372.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.26 Acremonium chrysogenum
-
-
-
6.3.2.26 Streptomyces clavuligerus
-
-
-

Storage Stability

EC Number Storage Stability Organism
6.3.2.26 -80°C, about 15% of activity after 10 months Acremonium chrysogenum
6.3.2.26 -80°C, no loss in activity after 6 weeks Acremonium chrysogenum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.26 DL-valine + L-O-(methylserine) + L-2-aminohexanedioate + ATP
-
 Acremonium chrysogenum L-O-(methylserinyl)-D-valine + L-O-(methylserinyl)-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + allylglycine + L-valine + ATP
-
 Acremonium chrysogenum L-delta-(aminoadipyl)-L-allylglycinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + allylglycine + L-valine + ATP
-
 Streptomyces clavuligerus L-delta-(aminoadipyl)-L-allylglycinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + L-cysteine + L-allo-isoleucine + ATP
-
 Acremonium chrysogenum L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + L-cysteine + L-allo-isoleucine + ATP
-
 Streptomyces clavuligerus L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + L-cysteine + L-valine + ATP
-
 Acremonium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + L-cysteine + L-valine + ATP
-
 Streptomyces clavuligerus N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + vinylglycine + L-valine + ATP
-
 Acremonium chrysogenum L-delta-(aminoadipyl)-L-vinylglycinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 L-2-aminoadipate + vinylglycine + L-valine + ATP
-
 Streptomyces clavuligerus L-delta-(aminoadipyl)-L-vinylglycinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 S-carboxymethylcysteine + L-cysteine + L-valine + ATP
-
 Acremonium chrysogenum L-S-carboxymethylcysteinyl-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?
6.3.2.26 S-carboxymethylcysteine + L-cysteine + L-valine + ATP
-
 Streptomyces clavuligerus L-S-carboxymethylcysteinyl-L-cysteinyl-D-valine + AMP + diphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.2.26 27
-
 assay at Acremonium chrysogenum

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.26 ATP
-
 Acremonium chrysogenum
6.3.2.26 ATP
-
 Streptomyces clavuligerus