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Literature summary extracted from

  • Ceruti, M.; Balliano, G.; Rocco, F.; Milla, P.; Arpicco, S.; Cattel, L.; Viola, F.
    Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases (2001), Lipids, 36, 629-636.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 (5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene IC50: 0.0015 mM Saccharomyces cerevisiae
5.4.99.7 (5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene IC50: 0.005 mM Sus scrofa
5.4.99.7 (5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene IC50: 0.00005 mM Saccharomyces cerevisiae
5.4.99.7 (5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene IC50: 0.001 mM Sus scrofa
5.4.99.7 (6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene IC50: 0.012 mM Saccharomyces cerevisiae
5.4.99.7 (6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene IC50: 0.0022 mM Sus scrofa
5.4.99.7 2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane IC50: 0.0025 mM Saccharomyces cerevisiae
5.4.99.7 2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane IC50: 0.006 mM Sus scrofa
5.4.99.7 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole IC50: 0.0035 mM Saccharomyces cerevisiae
5.4.99.7 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole IC50: 0.012 mM Sus scrofa
5.4.99.7 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane IC50: 0.00017 mM Saccharomyces cerevisiae
5.4.99.7 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane IC50: 0.00035 mM Sus scrofa
5.4.99.7 2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane IC50: 0.035 mM Saccharomyces cerevisiae
5.4.99.7 2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane IC50: 0.1 mM Sus scrofa
5.4.99.17 additional information vinyl sulfide and ketene dithioacetal derivates of truncated 2,3-ocidosqualene interact with active site of the enzyme Alicyclobacillus acidocaldarius

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Saccharomyces cerevisiae
-
-
-
5.4.99.7 Sus scrofa
-
-
-
5.4.99.17 Alicyclobacillus acidocaldarius
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.99.7 0.00005
-
IC50: 0.00005 mM Saccharomyces cerevisiae (5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene
5.4.99.7 0.00017
-
IC50: 0.00017 mM Saccharomyces cerevisiae 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane
5.4.99.7 0.00035
-
IC50: 0.00035 mM Sus scrofa 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane
5.4.99.7 0.001
-
IC50: 0.001 mM Sus scrofa (5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene
5.4.99.7 0.0015
-
IC50: 0.0015 mM Saccharomyces cerevisiae (5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene
5.4.99.7 0.0022
-
IC50: 0.0022 mM Sus scrofa (6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene
5.4.99.7 0.0025
-
IC50: 0.0025 mM Saccharomyces cerevisiae 2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane
5.4.99.7 0.0035
-
IC50: 0.0035 mM Saccharomyces cerevisiae 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole
5.4.99.7 0.005
-
IC50: 0.005 mM Sus scrofa (5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene
5.4.99.7 0.006
-
IC50: 0.006 mM Sus scrofa 2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane
5.4.99.7 0.012
-
IC50: 0.012 mM Saccharomyces cerevisiae (6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene
5.4.99.7 0.012
-
IC50: 0.012 mM Sus scrofa 2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole
5.4.99.7 0.035
-
IC50: 0.035 mM Saccharomyces cerevisiae 2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane
5.4.99.7 0.1
-
IC50: 0.1 mM Sus scrofa 2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane