EC Number | Application | Comment | Organism |
---|---|---|---|
1.10.3.6 | medicine | rifamycin, an ansa-macrolide antibiotic, is used for production of antituberculosic agents | Humicola spp. |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.10.3.6 | Fe2+ | - |
Humicola spp. | |
1.10.3.6 | Hg2+ | - |
Humicola spp. | |
1.10.3.6 | Rifamycin B | concentration above 2 mM | Humicola spp. |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.10.3.6 | 0.05 | - |
Rifamycin B | - |
Humicola spp. |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.10.3.6 | intracellular | - |
Humicola spp. | 5622 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.10.3.6 | additional information | not affected by other metal ions than Fe2+, Hg2+ | Humicola spp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.10.3.6 | rifamycin B + O2 | Humicola spp. | - |
rifamycin O + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.10.3.6 | Humicola spp. | - |
ATCC 20620 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.10.3.6 | partially, ammonium sulfate precipitation | Humicola spp. |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.10.3.6 | rifamycin B + O2 = rifamycin O + H2O2 | acts on various kinds of diphenol compounds, converting them into quinonic forms and H2O2 | Humicola spp. |
EC Number | Storage Stability | Organism |
---|---|---|
1.10.3.6 | 4°C, 100 mM phosphate buffer, pH 7.8, one month, no appreciable loss of activity | Humicola spp. |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.10.3.6 | catechol + O2 | - |
Humicola spp. | ? | - |
? | |
1.10.3.6 | p-hydroquinone + O2 | - |
Humicola spp. | ? | - |
? | |
1.10.3.6 | p-hydroxyphenoxyacetic acid + O2 | - |
Humicola spp. | ? | - |
? | |
1.10.3.6 | rifamycin B + O2 | - |
Humicola spp. | rifamycin O + H2O2 | - |
? | |
1.10.3.6 | rifamycin B + O2 | most specific, highest catalytic efficiency | Humicola spp. | rifamycin O + H2O2 | - |
? | |
1.10.3.6 | rifamycin SV + ? | - |
Humicola spp. | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.10.3.6 | 45 | - |
above the catalytic activity is greatly reduced | Humicola spp. |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.10.3.6 | 7.8 | 8 | - |
Humicola spp. |