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Literature summary extracted from
- Purification and iodinating activity of hog thyroid peroxidase (1967), J. Biol. Chem., 242, 5510-5523.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.8 | 1-Methyl-2-mercaptoimidazole | competitive with iodide | Sus scrofa |  |
| 1.11.1.8 | azide | very effective | Sus scrofa | |
| 1.11.1.8 | glutathione | - |
Sus scrofa | |
| 1.11.1.8 | Iodide | above 0.1 mM at pH 5, no inhibition at pH 7 | Sus scrofa | |
| 1.11.1.8 | p-Aminobenzoic acid | - |
Sus scrofa | |
| 1.11.1.8 | resorcinol | - |
Sus scrofa | |
| 1.11.1.8 | sulfathiazole | - |
Sus scrofa | |
| 1.11.1.8 | thiocyanate | competitive with iodide | Sus scrofa | |
| 1.11.1.8 | thiouracil | - |
Sus scrofa | |
| 1.11.1.8 | Thiourea | - |
Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.11.1.8 | 0.25 | - |
I- | - |
Sus scrofa | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.8 | 64000 | - |
gel filtration, analytical ultracentrifugation | Sus scrofa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.8 | iodide + H2O2 | Sus scrofa | iodination and coupling reactions of proteins | iodine + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.8 | Sus scrofa | - |
pig, female | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.8 | - |
Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.8 | intestine | - |
Sus scrofa | - |
| 1.11.1.8 | lymphoid tissue | - |
Sus scrofa | - |
| 1.11.1.8 | additional information | traces of activity in liver, kidney, heart, brain, ovary and muscle | Sus scrofa | - |
| 1.11.1.8 | salivary gland | - |
Sus scrofa | - |
| 1.11.1.8 | spleen | - |
Sus scrofa | - |
| 1.11.1.8 | thyroid gland | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.8 | 32 | - |
purified enzyme | Sus scrofa |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.11.1.8 | -20°C, 6-12 months, no loss of activity | Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.8 | iodide + H2O2 | highest activity if coupled with glucose-glucose oxidase reaction for H2O2 production | Sus scrofa | iodine + H2O | - |
? | |
| 1.11.1.8 | iodide + H2O2 | iodination and coupling reactions of proteins | Sus scrofa | iodine + H2O | - |
? | |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.8 | 5 | 7 | activity independent of pH | Sus scrofa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.8 | heme | - |
Sus scrofa | |
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