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Literature summary extracted from

  • Yamaguchi, K.; Hosokawa, Y.
    Cysteine dioxygenase (1987), Methods Enzymol., 143, 395-403.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.20 Carboxyethyl-L-cysteine at 10 mM, activation Rattus norvegicus
1.13.11.20 carboxymethyl-L-cysteine at 10 mM, activation Rattus norvegicus
1.13.11.20 cysteamine at 100 mM, activation Rattus norvegicus
1.13.11.20 D-cysteine at 10 mM, activation Rattus norvegicus
1.13.11.20 DL-homocysteine at 100 mM, slight activation Rattus norvegicus
1.13.11.20 hydrocortisone induces Rattus norvegicus
1.13.11.20 methionine induces Rattus norvegicus
1.13.11.20 N-acetyl-L-cysteine at 100 mM, slight activation Rattus norvegicus
1.13.11.20 NAD(P)H stimulation Rattus norvegicus
1.13.11.20 S-methyl-L-cysteine at 10 mM, activation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.20 Carboxyethyl-L-cysteine 53% inhibition at 1 mM Rattus norvegicus
1.13.11.20 carboxymethyl-L-cysteine 37% inhibition at 1 mM Rattus norvegicus
1.13.11.20 cysteamine 39% inhibition at 10 mM Rattus norvegicus
1.13.11.20 D-cysteine inhibition at 1 mM Rattus norvegicus
1.13.11.20 DL-homocysteine
-
Rattus norvegicus
1.13.11.20 N-acetyl-L-cysteine 35% inhibition at 10 mM Rattus norvegicus
1.13.11.20 S-methyl-L-cysteine 34% inhibition at 1 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.20 0.45
-
cysteine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.20 cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.20 Fe Fe2+ required, 0.8-0.9 gatom of iron per 22500 g of purified protein Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.20 22500
-
SDS-PAGE, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.20 Rattus norvegicus
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.13.11.20 rapid and irreversible inactivation under aerobic conditions, inactivation can be prevented by a distinct cytoplasmic protein, i.e. protein A Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.20 using acetone fractionation, column chromatography on DEAE-cellulose, Sephadex G-100, hydroxylapatite, DEAE-Sephadex A-25 and Sephadex G-75 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.20 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.20 additional information
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.13.11.20 0°C, no significant loss of activity after 1 month Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.20 L-cysteine + O2 highly specific for L-cysteine Rattus norvegicus 3-sulfino-L-alanine
-
?
1.13.11.20 additional information L-cystine, D-cysteine, carboxymethyl-L-cysteine, carboxyethyl-L-cysteine, S-methyl-L-cysteine, N-acetyl-L-cysteine, DL-homocysteine and cysteamine do not serve as substrates Rattus norvegicus ?
-
?

Subunits

EC Number Subunits Comment Organism
1.13.11.20 monomer 1 * 22500, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.20 37
-
assay at Rattus norvegicus