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Literature summary extracted from

  • Wetterholm, A.; Macchia, L.; Haeggstrom, J.Z.
    Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes (1994), Arch. Biochem. Biophys., 311, 253-271.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 additional information zinc inhibits leukotriene B4 formation due to a direct or indirect inhibitory effect on 5-lipoxygenase Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 leukocyte polymorphonuclear Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
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