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Literature summary extracted from
- Alterations in Leukotriene Synthase Activity of the Human 5-Lipoxygenase by Site-Directed Mutagenesis Affecting Its Positional Specificity (2000), Biochemistry, 39, 14515-14521.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | F359W/A4241 | 8-lipoxygenating mutant | Homo sapiens |
| 1.13.11.34 | F359W/A424I/N425M/A603I | 15-lipoxygenating mutant | Homo sapiens |
| 1.13.11.34 | F359W/A424I/N425M/A603I | produces only minor amounts of leukotriene A4 | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.13.11.34 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | leukocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | + minor amounts of the double oxygenation products | ? |  |
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Release 2023.1 (January 2023)
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