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Literature summary extracted from
- Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis (2001), Chem. Biol., 8, 779-790.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.13.11.34 | wild-type and mutant enzyme F359W/A424I/N425M/A603I, expression in Escherichia coli | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | F359W/A424I/N425M/A603I | 15-lipoxygenating mutant | Homo sapiens |
| 1.13.11.34 | F359W/A424I/N425M/A603I | oxygenates polyenoic fatty acids containing C11=C12 and C14=C15 double bonds, C20:DELTA11,14,17, C20:DELTA11,14, C18:DELTA9,12, C18:DELTA6,9,12 and C18:DELTA9,12,15 which are not oxygenated by the wild-type enzyme. C20:DELTA5,8,11 that lacks the C11=C12 double bond is not oxygenated | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
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