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Literature summary extracted from

  • Ghosh, J.; Myers, C.E.
    Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells (1998), Proc. Natl. Acad. Sci. USA, 95, 13182-13187.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 MK 886 i.e. CAS: 118414-82-7, inhibition of 5-lipoxygenase in prostate cancer cells blocks production of 5-hydroxyeicosatetraenoic acid and induces massive apoptosisin both hormone-responsive and hormone-nonresponsive prostate cancer cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 prostate cancer cell constitutive production of 5-hydroxyeicosatetraenoic acid Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
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